Overview

  • Product nameAnti-DFNB31 antibody
    See all DFNB31 primary antibodies
  • Description
    Mouse monoclonal to DFNB31
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: GLLEPTSTLV RVKKSAATLG IAIEGGANTR QPLPRIVTIQ RGGSAHNCGQ LKVGHVILEV NGLTLRGKEH REAARIIAEA FKTKDRDYID FLVTEFNVML , corresponding to amino acids 808-908 of Human DFNB31

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG2b
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab57106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionNecessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear.
    • Involvement in diseaseDefects in WHRN are the cause of deafness autosomal recessive type 31 (DFNB31) [MIM:607084]. DFNB31 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
      Defects in WHRN are the cause of Usher syndrome type 2D (USH2D) [MIM:611383]. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH2 is characterized by congenital mild hearing impairment with normal vestibular responses.
    • Sequence similaritiesContains 3 PDZ (DHR) domains.
    • Cellular localizationCytoplasm. Cell projection > stereocilium. Cell projection > growth cone. Detected at the level of stereocilia in inner outer hair cells of the cochlea and vestibule. Co-localizes with the growing ends of actin filaments (By similarity). Colocalizes with MPP1 in the retina, at the outer limiting membrane (OLM), outer plexifirm layer (OPL), basal bodies and at the connecting cilium.
    • Information by UniProt
    • Database links
    • FormThere are 4 isoforms produced by alternative splicing.
    • Alternative names
      • 1110035G07Rik antibody
      • Autosomal recessive deafness type 31 protein antibody
      • CASK interacting protein CIP98 antibody
      • CIP 98 antibody
      • CIP98 antibody
      • Deafness autosomal recessive 31 antibody
      • DFNB 31 antibody
      • DKFZp434N014 antibody
      • KIAA1526 antibody
      • RP11 9M16.1 antibody
      • USH 2D antibody
      • USH2D antibody
      • Whirlin antibody
      • WHRN antibody
      • WHRN_HUMAN antibody
      • WI antibody
      see all

    Anti-DFNB31 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57106 DFNB31 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-DFNB31 antibody (ab57106)

    ab57106 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab57106.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"