• Product nameAnti-Dhh antibody
    See all Dhh primary antibodies
  • Description
    Mouse polyclonal to Dhh
  • SpecificityAntibody reactive against mammalian transfected lysate.
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-396 of Human Dhh

  • Positive control
    • Transfected 293T cell lysate



Our Abpromise guarantee covers the use of ab67461 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: 1/500 - 1/1000. Detects a band of approximately 44 kDa (predicted molecular weight: 44 kDa).
    Detection Pair

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionIntercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
    • Involvement in diseaseDefects in DHH may be the cause of partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD) [MIM:607080]. PGD is characterized by the presence of a testis on one side and a streak or an absent gonad at the other, persistence of Muellerian duct structures, and a variable degree of genital ambiguity.
      Defects in DHH may be the cause of complete pure gonadal dysgenesis 46,XY type (GDXYM) [MIM:233420]; also known as male-limited gonadal dysgenesis 46,XY. GDXYM is a type of hypogonadism in which no functional gonads are present to induce puberty in an externally female person whose karyotype is then found to be XY. The gonads are found to be non-functional streaks.
    • Sequence similaritiesBelongs to the hedgehog family.
    • Post-translational
      The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). This covalent modification appears to play an essential role in restricting the spatial distribution of the protein activity to the cell surface. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.
    • Cellular localizationSecreted > extracellular space. The C-terminal peptide diffuses from the cell and Cell membrane. The N-terminal peptide remains associated with the cell surface.
    • Information by UniProt
    • Database links
    • Alternative names
      • C78960 antibody
      • Desert hedgehog (Drosophila) homolog antibody
      • Desert hedgehog antibody
      • Desert hedgehog homolog (Drosophila) antibody
      • Desert hedgehog protein C-product antibody
      • Desert hedgehog protein precursor antibody
      • DHH antibody
      • DHH_HUMAN antibody
      • GDXYM antibody
      • HHG-3 antibody
      • Hira antibody
      • SRXY7 antibody
      see all

    Anti-Dhh antibody images

    • All lanes : Anti-Dhh antibody (ab67461) at 1/500 dilution

      Lane 1 : Transfected 293T cell lysate
      Lane 2 : non Transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

      Predicted band size : 44 kDa
      Observed band size : 44 kDa

    References for Anti-Dhh antibody (ab67461)

    ab67461 has not yet been referenced specifically in any publications.

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