Overview

  • Product nameAnti-Dhh antibody
    See all Dhh primary antibodies
  • Description
    Rabbit polyclonal to Dhh
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 135-388 of Human Dhh (NP_066382)

  • Positive control
    • 293T; Jurkat or Raji lysates and A431 whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab97287 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 44 kDa.

Target

  • FunctionIntercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
  • Involvement in diseaseDefects in DHH may be the cause of partial gonadal dysgenesis with minifascicular neuropathy 46,XY (PGD) [MIM:607080]. PGD is characterized by the presence of a testis on one side and a streak or an absent gonad at the other, persistence of Muellerian duct structures, and a variable degree of genital ambiguity.
    Defects in DHH may be the cause of complete pure gonadal dysgenesis 46,XY type (GDXYM) [MIM:233420]; also known as male-limited gonadal dysgenesis 46,XY. GDXYM is a type of hypogonadism in which no functional gonads are present to induce puberty in an externally female person whose karyotype is then found to be XY. The gonads are found to be non-functional streaks.
  • Sequence similaritiesBelongs to the hedgehog family.
  • Post-translational
    modifications
    The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). This covalent modification appears to play an essential role in restricting the spatial distribution of the protein activity to the cell surface. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.
  • Cellular localizationSecreted > extracellular space. The C-terminal peptide diffuses from the cell and Cell membrane. The N-terminal peptide remains associated with the cell surface.
  • Information by UniProt
  • Database links
  • Alternative names
    • C78960 antibody
    • Desert hedgehog (Drosophila) homolog antibody
    • Desert hedgehog antibody
    • Desert hedgehog homolog (Drosophila) antibody
    • Desert hedgehog protein C-product antibody
    • Desert hedgehog protein precursor antibody
    • DHH antibody
    • DHH_HUMAN antibody
    • GDXYM antibody
    • HHG-3 antibody
    • Hira antibody
    • SRXY7 antibody
    see all

Anti-Dhh antibody images

  • Anti-Dhh antibody (ab97287) at 1/10000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 44 kDa

References for Anti-Dhh antibody (ab97287)

ab97287 has not yet been referenced specifically in any publications.

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