Overview

  • Product nameAnti-DHX58 antibody
    See all DHX58 primary antibodies
  • Description
    Rabbit polyclonal to DHX58
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide corresponding to 11 internal sequence amino acids of Human DHX58 (NP_077024.2).

  • Positive control
    • Rat kidney tissue lysate; Human Brain, Cortex tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab115674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 77 kDa.
ELISA Use at an assay dependent concentration.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionParticipates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower.
  • Sequence similaritiesBelongs to the helicase family.
    Contains 1 helicase ATP-binding domain.
    Contains 1 helicase C-terminal domain.
  • Cellular localizationCytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • D11LGP2 antibody
    • D11lgp2e antibody
    • DEXH (Asp Glu X His) box polypeptide 58 antibody
    • DEXH box polypeptide 58 antibody
    • DHX 58 antibody
    • DHX58 antibody
    • DHX58_HUMAN antibody
    • LGP 2 antibody
    • LGP2 antibody
    • Ortholog of mouse D11lgp2 antibody
    • Probable ATP dependent helicase LGP2 antibody
    • Probable ATP dependent RNA helicase DHX58 antibody
    • Probable ATP-dependent helicase LGP2 antibody
    • Probable ATP-dependent RNA helicase DHX58 antibody
    • Protein D11Lgp2 homolog antibody
    • RIG-I-like receptor LGP2 antibody
    • RLR antibody
    • RNA helicase LGP2 antibody
    see all

Anti-DHX58 antibody images

  • Lane 1 : Anti-DHX58 antibody (ab115674) at 1 µg/ml
    Lane 2 : Anti-DHX58 antibody (ab115674) at 2 µg/ml

    Lane 1 : Rat kidney tissue lysate
    Lane 2 : Rat kidney tissue lysate


    Predicted band size : 77 kDa
  • ab115674, at 5µg/ml, staining DHX58 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References for Anti-DHX58 antibody (ab115674)

ab115674 has not yet been referenced specifically in any publications.

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