Overview

  • Product name
  • Description
    Rabbit polyclonal to DHX58
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    An 11 amino acid synthetic peptide from near the centre of human DHX58.

  • Positive control
    • Rat kidney tissue lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab67272 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 1 - 2 µg/ml. Detects a bands of approximately 45 & 77 kDa (predicted molecular weight: 45 & 77 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Participates in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade which results in the induction and expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). The RNA helicase domain may recognize and structurally modify viral RNA to facilitate detection by DDX58/RIG-I or by IFIH1/MDA5 whose affinity for dsRNA is lower.
    • Sequence similarities
      Belongs to the helicase family.
      Contains 1 helicase ATP-binding domain.
      Contains 1 helicase C-terminal domain.
    • Cellular localization
      Cytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • D11LGP2 antibody
      • D11lgp2e antibody
      • DEXH (Asp Glu X His) box polypeptide 58 antibody
      • DEXH box polypeptide 58 antibody
      • DHX 58 antibody
      • DHX58 antibody
      • DHX58_HUMAN antibody
      • LGP 2 antibody
      • LGP2 antibody
      • Ortholog of mouse D11lgp2 antibody
      • Probable ATP dependent helicase LGP2 antibody
      • Probable ATP dependent RNA helicase DHX58 antibody
      • Probable ATP-dependent helicase LGP2 antibody
      • Probable ATP-dependent RNA helicase DHX58 antibody
      • Protein D11Lgp2 homolog antibody
      • RIG-I-like receptor LGP2 antibody
      • RLR antibody
      • RNA helicase LGP2 antibody
      see all

    Images

    • Lane 1 : Anti-DHX58 antibody (ab67272) at 1 µg/ml
      Lane 2 : Anti-DHX58 antibody (ab67272) at 2 µg/ml

      Lane 1 : Rat kidney tissue lysate
      Lane 2 : Rat kidney tissue lysate

      Lysates/proteins at 15 µg per lane.

      Secondary
      anti rabbit secondary antibody

      Predicted band size : 45, 77 kDa
      Observed band size : 45,77 kDa

    References

    ab67272 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab67272.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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