Overview

  • Product name
    DIAPH2 peptide

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab156990 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

General Info

  • Alternative names
    • DIA
    • Dia 2
    • Dia drome
    • Dia2
    • Diap 2
    • Diap2
    • DIAP2_HUMAN
    • DIAPH 2
    • Diaph2
    • Diaphanous 2
    • Diaphanous homolog 2
    • Diaphanous homolog 2 (Drosophila)
    • Diaphanous related formin 2
    • Diaphanous-related formin-2
    • Diaphanous2
    • Diaphorase 2
    • Diaphorase2
    • DRF 2
    • DRF2
    • FLJ11167
    • OTTHUMP00000024270
    • OTTHUMP00000024271
    • OTTHUMP00000062171
    • POF
    • POF 2
    • POF2
    • Protein diaphanous homolog 2
    see all
  • Function
    Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton.
  • Tissue specificity
    Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.
  • Involvement in disease
    Defects in DIAPH2 are the cause of premature ovarian failure type 2A (POF2A) [MIM:300511]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
  • Sequence similarities
    Belongs to the formin homology family. Diaphanous subfamily.
    Contains 1 DAD (diaphanous autoregulatory) domain.
    Contains 1 FH1 (formin homology 1) domain.
    Contains 1 FH2 (formin homology 2) domain.
    Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
  • Developmental stage
    Expressed from E16 in ovary and testis and during P6-P16 during differentiation of ovarian follicles.
  • Domain
    DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction.
  • Cellular localization
    Cytoplasm > cytosol. Early endosome. Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
  • Information by UniProt

References

ab156990 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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