Overview

  • Product nameDIDS
  • Description
    Generic chloride channel blocker.
  • Alternative names
    • 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid, Disodium Salt
  • Biological description

    Stilbene disulfonate that inhibits anionic transport. Used to inhibit Cl- uptake through plasma membrane-localized Cl- channels in order to study chloride transport. Also effectively inhibits various sodium-coupled bicarbonate transporters. Reacts with CD4 glycoprotein on T helper lymphocytes and macrophages, blocking HIV type-1 growth at multiple stages of the viral life cycle.

  • General notes

    Fluorescence: max. Abs. l = 341, max. Em. l = 415 (in water).

     

Properties

  • Chemical name4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid disodium salt
  • Molecular weight498.50
  • Chemical structureChemical Structure
  • Molecular formulaC16H8N2Na2O6S4
  • CAS Number67483-13-0
  • Storage instructionsStore at -20°C. Store at -20°C long term. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under Desiccating conditions.
  • Solubility overviewSoluble in DMSO and in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

    References for DIDS (ab120277)

    This product has been referenced in:
    • Pusch M  et al. Channel or transporter? The CLC saga continues. Exp Physiol 91:149-52 (2006). Read more (PubMed: 16179405) »
    • Picollo A  et al. Molecular determinants of differential pore blocking of kidney CLC-K chloride channels. EMBO Rep 5:584-9 (2004). Read more (PubMed: 15167890) »
    • Boron WF Sodium-coupled bicarbonate transporters. JOP 2:176-81 (2001). Read more (PubMed: 11875256) »
    • Horie S  et al. Effects of 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, an inhibitor of Cl(-)-HCO3- exchanger, on stress-induced gastric lesions in rats. Res Commun Chem Pathol Pharmacol 79:117-20 (1993). Read more (PubMed: 8434127) »
    • Mayinger P & Meyer DI An ATP transporter is required for protein translocation into the yeast endoplasmic reticulum. EMBO J 12:659-66 (1993). Read more (PubMed: 8440256) »
    • Cardin AD  et al. Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle. J Biol Chem 266:13355-63 (1991). Read more (PubMed: 2071607) »

    See 0 Publications for this product

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