4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid, Disodium Salt
Stilbene disulfonate that inhibits anionic transport. Used to inhibit Cl- uptake through plasma membrane-localized Cl- channels in order to study chloride transport. Also effectively inhibits various sodium-coupled bicarbonate transporters. Reacts with CD4 glycoprotein on T helper lymphocytes and macrophages, blocking HIV type-1 growth at multiple stages of the viral life cycle.
Fluorescence: max. Abs. l = 341, max. Em. l = 415 (in water).
Chemical name4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid disodium salt
Storage instructionsStore at -20°C. Store at -20°C long term. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under Desiccating conditions.
Solubility overviewSoluble in DMSO and in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Horie S et al. Effects of 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, an inhibitor of Cl(-)-HCO3- exchanger, on stress-induced gastric lesions in rats. Res Commun Chem Pathol Pharmacol79:117-20 (1993).
Read more (PubMed: 8434127) »
Mayinger P & Meyer DI An ATP transporter is required for protein translocation into the yeast endoplasmic reticulum. EMBO J12:659-66 (1993).
Read more (PubMed: 8440256) »
Cardin AD et al. Stilbene disulfonic acids. CD4 antagonists that block human immunodeficiency virus type-1 growth at multiple stages of the virus life cycle. J Biol Chem266:13355-63 (1991).
Read more (PubMed: 2071607) »