Biological descriptionSelective H2 agonist. Some selectivity for H3. Does not readily cross the blood-brain barrier. Systemically active following oral administration.
Chemical nameCarbamimidothioic acid 3-(dimethylamino)propyl ester dihydrochloride
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Nakamura T et al. Efficacy of a selective histamine H2 receptor agonist, dimaprit, in experimental models of endotoxin shock and hepatitis in mice. Eur J Pharmacol322:83-9 (1997).
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Coruzzi G et al. Cardiovascular effects of the novel histamine H2 receptor agonist amthamine: interaction with the adrenergic system. Naunyn Schmiedebergs Arch Pharmacol353:417-22 (1996).
Read more (PubMed: 8935708) »