Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab87369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Purity
    70 - 90% by HPLC.

  • Form
    Liquid
  • Additional notes

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

General Info

  • Alternative names
    • 5DII
    • D2
    • Deiodinase, iodothyronine, type II
    • DIO2
    • DIOII
    • EC 1.97.1.10
    • IOD2_HUMAN
    • ITDI2
    • SelY
    • Thyroxine deiodinase, type II
    • TXDI2
    • Type 2 DI
    • Type 2 iodothyronine deiodinase
    • Type II 5' deiodinase
    • Type II iodothyronine deiodinase
    • Type-II 5''-deiodinase
    see all
  • Function
    Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
  • Tissue specificity
    Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain.
  • Sequence similarities
    Belongs to the iodothyronine deiodinase family.
  • Post-translational
    modifications
    Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33.
  • Cellular localization
    Membrane.
  • Information by UniProt

References for DIO2 peptide (ab87369)

ab87369 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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