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Rabbit polyclonal to Dio3
Synthetic peptide conjugated to KLH, corresponding to a region within the C terminal amino acids 249-278 of Human Dio3 (NP_001353).
HepG2 cell line lysates. Human hepatocarcinoma tissue.
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Preservative: 0.09% Sodium Azide
Concentration information loading...
Immunogen affinity purified
ab102926 is purified through a protein A column, followed by peptide affinity purification.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 34 kDa.
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Expressed in placenta and several fetal tissues.
Belongs to the iodothyronine deiodinase family.
Cell membrane. Endosome membrane.
Information by UniProt
Deiodinase iodothyronine type 3 antibody
Western blot - Dio3 antibody (ab102926)
Anti-Dio3 antibody (ab102926) at 1/100 dilution + HepG2 cell line lysate at 35 µg
Predicted band size : 34 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Dio3 antibody [RB24089] (ab102926)
ab102926 at 1/50 staining Dio3 in Formalin-fixed and paraffin-embedded Human hepatocarcinoma by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.
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