Biological descriptionPotent H1 receptor antagonist (Ki = 1 nM). Shows antihistaminergic, antiemetic, sedative and hypnotic effects.
Chemical name2-Diphenylmethoxy-N,N-dimethylethanamine hydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Au-Yeung SC et al. A pharmacokinetic study of diphenhydramine transport across the blood-brain barrier in adult sheep: potential involvement of a carrier-mediated mechanism. Drug Metab Dispos34:955-60 (2006).
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Liu H & Farley JM Effects of first and second generation antihistamines on muscarinic induced mucus gland cell ion transport. BMC Pharmacol5:8 (2005).
Read more (PubMed: 15790419) »