Anti-DIRAS1 antibody - Carboxyterminal end (ab65139)

Overview

  • Product name
    Anti-DIRAS1 antibody - Carboxyterminal end
    See all DIRAS1 primary antibodies
  • Description
    Rabbit polyclonal to DIRAS1 - Carboxyterminal end
  • Specificity
    This antibody detects endogenous levels of total DIRAS1 protein.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A synthesized peptide derived from the C-terminal of human DIRAS1

  • Positive control
    • Extracts from Hela and HepG2 cells

Properties

Applications

Our Abpromise guarantee covers the use of ab65139 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/20000.
WB 1/500 - 1/1000. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).

Target

  • Relevance
    The three human RAS genes encode highly related 188 to 189 amino acid proteins, designated H-Ras, N-Ras and K-Ras4A and K-Ras4B (the two K-Ras proteins arise from alternative gene splicing). Ras proteins function as binary molecular switches that control intracellular signaling networks. Ras-regulated signal pathways control such processes as actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. Ras and ras-related proteins are often deregulated in cancers, leading to increased invasion and metastasis, and decreased apoptosis. DIRAS1 displays low GTPase activity and exists predominantly in the GTP-bound form. It is highly expressed in heart and brain.
  • Cellular localization
    Cell membrane; Lipid-anchor; Cytoplasmic side
  • Database links
  • Alternative names
    • Di Ras1 antibody
    • DIRAS family GTP binding RAS like 1 antibody
    • Distinct subgroup of the Ras family member 1 antibody
    • FLJ42681 antibody
    • GBTS1 antibody
    • GTP binding protein Di Ras1 antibody
    • Ras related inhibitor of cell growth antibody
    • RIG antibody
    • Rig protein antibody
    • Small GTP binding tumor suppressor 1 antibody
    see all

Images

  • All lanes : Anti-DIRAS1 antibody - Carboxyterminal end (ab65139) at 1/500 dilution

    Lane 1 : Extracts from Hela cells
    Lane 2 : Extracts from HepG2 cells
    Lane 3 : Extracts from HepG2 cells, plus immunising peptide


    Predicted band size : 22 kDa
    Observed band size : 22 kDa

References

ab65139 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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