Overview

  • Product nameAnti-DIS antibody
    See all DIS primary antibodies
  • Description
    Rabbit polyclonal to DIS
  • Tested applicationsSuitable for: IP, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Dog, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Platypus (Ornithorhynchus anatinus), Elephant
  • Immunogen

    Synthetic peptide (Human) - which represents a portion of Death Inducer with SAP domain encoded within exon 17.

  • Positive control
    • HeLa cell nuclear extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab3743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use a concentration of 1 - 4 µg/ml.
WB 1/2000 - 1/10000. Predicted molecular weight: 140 kDa.

Target

  • FunctionAssociates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
  • Tissue specificityExpressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
  • Sequence similaritiesContains 1 SAP domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > perinuclear region.
  • Information by UniProt
  • Database links
  • Alternative names
    • CARP-1 antibody
    • Carp1 antibody
    • Ccar1 antibody
    • CCAR1_HUMAN antibody
    • Cell cycle and apoptosis regulatory protein 1 antibody
    • cell division cycle and apoptosis regulator 1 antibody
    • Cell division cycle and apoptosis regulator protein 1 antibody
    • Death inducer with SAP domain antibody
    • FLJ10590 antibody
    • FLJ10839 antibody
    • FLJ13376 antibody
    • FLJ20734 antibody
    • MGC7730 antibody
    • RP11-437A18.1 antibody
    see all

Anti-DIS antibody images



  • Predicted band size : 140 kDa


    Sample: Nuclear extract from HeLa cells (50µg)

    Antibody: Affinity purified Rabbit anti-DIS (ab3743) used at 1 / 2000 dilution.

    Detection: ECL.

References for Anti-DIS antibody (ab3743)

ab3743 has not yet been referenced specifically in any publications.

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