• Product name
  • Description
    Rabbit polyclonal to DIS
  • Tested applications
    Suitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residues 100 and 150 of human DIS. (Q8IX12).

  • Positive control
    • Nuclear extract from HeLa cells



Our Abpromise guarantee covers the use of ab70244 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IP: Use at 1-10µg/mg of lysate.
    WB: 1/1000 - 1/5000. Detects a band of approximately 132 kDa (predicted molecular weight: 132 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
    • Tissue specificity
      Expressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
    • Sequence similarities
      Contains 1 SAP domain.
    • Post-translational
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localization
      Cytoplasm > perinuclear region.
    • Information by UniProt
    • Database links
    • Alternative names
      • CARP-1 antibody
      • Carp1 antibody
      • Ccar1 antibody
      • CCAR1_HUMAN antibody
      • Cell cycle and apoptosis regulatory protein 1 antibody
      • cell division cycle and apoptosis regulator 1 antibody
      • Cell division cycle and apoptosis regulator protein 1 antibody
      • Death inducer with SAP domain antibody
      • FLJ10590 antibody
      • FLJ10839 antibody
      • FLJ13376 antibody
      • FLJ20734 antibody
      • MGC7730 antibody
      • RP11-437A18.1 antibody
      see all

    Anti-DIS antibody images

    • All lanes : Anti-DIS antibody (ab70244) at 1 µg/ml

      Lane 1 : Nuclear extract from HeLa cells at 15 µg
      Lane 2 : Nuclear extract from HeLa cells at 45 µg

      Predicted band size : 132 kDa
      Observed band size : 132 kDa

      Exposure time : 1 minute

    References for Anti-DIS antibody (ab70244)

    This product has been referenced in:
    • Mizuta S  et al. CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel pathway for GATA1 function. Genes Cells 19:28-51 (2014). Read more (PubMed: 24245781) »

    See 1 Publication for this product

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