Overview

  • Product nameAnti-DIS antibody
    See all DIS primary antibodies
  • Description
    Rabbit polyclonal to DIS
  • Tested applicationsSuitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to a region between residues 100 and 150 of human DIS. (Q8IX12).

  • Positive control
    • Nuclear extract from HeLa cells

Properties

Applications

Our Abpromise guarantee covers the use of ab70244 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IP
  • Application notesIP: Use at 1-10µg/mg of lysate.
    WB: 1/1000 - 1/5000. Detects a band of approximately 132 kDa (predicted molecular weight: 132 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAssociates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
    • Tissue specificityExpressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
    • Sequence similaritiesContains 1 SAP domain.
    • Post-translational
      modifications
      Phosphorylated upon DNA damage, probably by ATM or ATR.
    • Cellular localizationCytoplasm > perinuclear region.
    • Information by UniProt
    • Database links
    • Alternative names
      • CARP-1 antibody
      • Carp1 antibody
      • Ccar1 antibody
      • CCAR1_HUMAN antibody
      • Cell cycle and apoptosis regulatory protein 1 antibody
      • cell division cycle and apoptosis regulator 1 antibody
      • Cell division cycle and apoptosis regulator protein 1 antibody
      • Death inducer with SAP domain antibody
      • FLJ10590 antibody
      • FLJ10839 antibody
      • FLJ13376 antibody
      • FLJ20734 antibody
      • MGC7730 antibody
      • RP11-437A18.1 antibody
      see all

    Anti-DIS antibody images

    • All lanes : Anti-DIS antibody (ab70244) at 1 µg/ml

      Lane 1 : Nuclear extract from HeLa cells at 15 µg
      Lane 2 : Nuclear extract from HeLa cells at 45 µg


      Predicted band size : 132 kDa
      Observed band size : 132 kDa


      Exposure time : 1 minute

    References for Anti-DIS antibody (ab70244)

    ab70244 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab70244.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"