Overview

  • Product nameAnti-DIS antibody
    See all DIS primary antibodies
  • Description
    Rabbit polyclonal to DIS
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Dog, Turkey, Chimpanzee, Rhesus monkey, Gorilla, Tilapia, Orangutan
  • Immunogen

    Synthetic peptide within Human DIS aa 1-50. The exact sequence is proprietary.
    Database link: 55749

  • Positive control
    • Human skin basal cell carcinoma and Mouse squamous cell carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84425 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Epitope exposure is recommended (exposure with citrate buffer will enhance staining). Likely to work with frozen sections.

Target

  • FunctionAssociates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
  • Tissue specificityExpressed in various epithelial cancer cell lines, including breast, colon, prostate, pancreatic and leukemia. Expression is regulated by growth factors.
  • Sequence similaritiesContains 1 SAP domain.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationCytoplasm > perinuclear region.
  • Information by UniProt
  • Database links
  • Alternative names
    • CARP-1 antibody
    • Carp1 antibody
    • Ccar1 antibody
    • CCAR1_HUMAN antibody
    • Cell cycle and apoptosis regulatory protein 1 antibody
    • cell division cycle and apoptosis regulator 1 antibody
    • Cell division cycle and apoptosis regulator protein 1 antibody
    • Death inducer with SAP domain antibody
    • FLJ10590 antibody
    • FLJ10839 antibody
    • FLJ13376 antibody
    • FLJ20734 antibody
    • MGC7730 antibody
    • RP11-437A18.1 antibody
    see all

Anti-DIS antibody images

  • ab84425, at 1/250 dilution, staining DIS in formalin-fixed, paraffin-embedded human skin basal cell carcinoma by Immunohistochemistry using DAB detection and an anti-Rabbit IgG HRP conjugated secondary antibody at a dilution of 1/100.
  • ab84425, at 1/250 dilution, staining DIS in formalin-fixed, paraffin-embedded mouse squamous cell carcinoma by Immunohistochemistry using DAB detection and an anti-Rabbit IgG HRP conjugated secondary antibody at a dilution of 1/100.

References for Anti-DIS antibody (ab84425)

ab84425 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"