• Product nameAnti-DISC1 antibody
    See all DISC1 primary antibodies
  • Description
    Rabbit polyclonal to DISC1
  • Tested applicationsSuitable for: WB, ICC/IF, ICCmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Raised against an 18 amino acid peptide from near the center of human DISC1.

  • Positive control
    • SK-N-SH cytoplasmic, mitochondrial or nuclear lysate


Associated products


Our Abpromise guarantee covers the use of ab62069 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 94 kDa (predicted molecular weight: 94 kDa).
ICC/IF Use a concentration of 20 µg/ml.
ICC Use a concentration of 5 µg/ml.


  • FunctionInvolved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
  • Tissue specificityUbiquitous. Highly expressed in the dentate gyrus of the hippocampus. Also expressed in the temporal and parahippocampal cortices and cells of the white matter.
  • Involvement in diseaseNote=A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3). The truncated DISC1 protein produced by this translocation is unable to interact with ATF4, ATF5 and NDEL1.
    Genetic variation in DISC1 is associated with susceptibility to schizophrenia type 9 (SCZD9) [MIM:604906]. A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
  • Developmental stageExpression rises within the dentate gyrus and temporal cortex from the neonatal period to infancy, declines markedly in adolescence, and declines further with aging.
  • Cellular localizationCytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > centrosome. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Colocalizes with NDEL1 in the perinuclear region and the centrosome (By similarity). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • C1orf136 antibody
    • DISC1 antibody
    • DISC1_HUMAN antibody
    • Disrupted in schizophrenia 1 antibody
    • Disrupted in schizophrenia 1 protein antibody
    • KIAA0457 antibody
    • RP4-730B13.1 antibody
    • SCZD9 antibody
    see all

Anti-DISC1 antibody images

  • Lane 1 : Anti-DISC1 antibody (ab62069) at 0.5 µg/ml
    Lane 2 : Anti-DISC1 antibody (ab62069) at 1 µg/ml
    Lane 3 : Anti-DISC1 antibody (ab62069) at 2 µg/ml

    Lane 1 : SK-N-SH cell lysate
    Lane 2 : SK-N-SH cell lysate
    Lane 3 : SK-N-SH cell lysate

    Lysates/proteins at 10 µg per lane.

    anti-rabbit IgG

    Predicted band size : 94 kDa
    Observed band size : 94 kDa
  • ab62069 at 5µg/ml staining DISC1 in human Hela cells by Immunohistochemistry.

  • Immunofluorescence of DISC1 in Hela cells using ab62069 at 20 ug/ml.

References for Anti-DISC1 antibody (ab62069)

ab62069 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us. The immunogen is 18 amino acids long which correspond to amino acids 300 - 400 of human DISC1 protein. I am sorry this is the only information we can disclose; we unfortunately will not be able to confirm the exact loca...

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