Overview

  • Product name
  • Description
    Rabbit polyclonal to DISP2
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    N-Terminus of Human DISP2

  • Positive control
    • Human Small Intestine tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab113837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.

Target

  • Relevance
    DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist.
  • Cellular localization
    Membrane; Multi-pass membrane protein.
  • Database links
  • Alternative names
    • DISP 2 antibody
    • Dispatched B antibody
    • Dispatched homolog 2 (Drosophila) antibody
    • Dispatched homolog 2 antibody
    • DISPB antibody
    • DKFZp547N223 antibody
    • HsT16908 antibody
    • KIAA1742 antibody
    • Protein dispatched homolog 2 antibody
    see all

Images

  • ab113837, at 5µg/ml, staining DISP2 in formalin-fixed, paraffin-embedded Human Small Intestine tissue by Immunohistochemistry.

References

ab113837 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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