• Product nameAnti-DKC1 antibody
    See all DKC1 primary antibodies
  • Description
    Rabbit polyclonal to DKC1
  • SpecificityDetects endogenous levels of total DKC1 protein.
  • Tested applicationsSuitable for: WB, ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide from internal of human Dyskerin.

  • Positive control
    • HeLa cells and extracts from HeLa cells.



Our Abpromise guarantee covers the use of ab64955 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).
ICC/IF 1/500 - 1/1000.
ELISA 1/10000.


  • FunctionIsoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.
    Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).
  • Tissue specificityUbiquitously expressed.
  • Involvement in diseaseDefects in DKC1 are a cause of dyskeratosis congenita X-linked recessive (XDKC) [MIM:305000]. XDKC is a rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
    Defects in DKC1 are the cause of Hoyeraal-Hreidarsson syndrome (HHS) [MIM:300240]. HHS is a multisystem disorder affecting males and is characterized by aplastic anemia, immunodeficiency, microcephaly, cerebellar hypoplasia, and growth retardation.
  • Sequence similaritiesBelongs to the pseudouridine synthase TruB family.
    Contains 1 PUA domain.
  • Cellular localizationCytoplasm and Nucleus > nucleolus. Nucleus > Cajal body. Also localized to Cajal bodies.
  • Information by UniProt
  • Database links
  • Alternative names
    • CBF5 antibody
    • CBF5 homolog antibody
    • Cbf5p homolog antibody
    • DKC 1 antibody
    • DKC antibody
    • Dkc1 antibody
    • DKC1_HUMAN antibody
    • DKCX antibody
    • Dyskeratosis congenita 1 antibody
    • Dyskeratosis congenita 1 dyskerin antibody
    • Dyskerin antibody
    • H/ACA ribonucleoprotein complex subunit 4 antibody
    • NAP 57 antibody
    • NAP57 antibody
    • NOLA 4 antibody
    • NOLA4 antibody
    • Nopp140 associated protein of 57 kDa antibody
    • Nopp140-associated protein of 57 kDa antibody
    • Nucleolar protein family A member 4 antibody
    • Nucleolar protein NAP57 antibody
    • snoRNP protein DKC1 antibody
    • XAP 101 antibody
    • XAP101 antibody
    see all

Anti-DKC1 antibody images

  • All lanes : Anti-DKC1 antibody (ab64955) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : HeLa cell extract with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 58 kDa
    Observed band size : 58 kDa
    Additional bands at : 45 kDa. We are unsure as to the identity of these extra bands.
  • Immunofluorescence analysis of HeLa cells, using ab64955 at 1/500 dilution. Right hand panel was also treated with immunising peptide.

References for Anti-DKC1 antibody (ab64955)

ab64955 has not yet been referenced specifically in any publications.

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