Overview

  • Product nameAnti-Dkk3 antibody
    See all Dkk3 primary antibodies
  • Description
    Goat polyclonal to Dkk3
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    AAAALLGGEEI

    with a Cysteine residue linker, corresponding to C terminal amino acids 340-350 of Human Dkk3 (NP_037385.2).

  • Positive control
    • Human brain cortex tissue; HEK293 lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage bufferpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.03 - 0.1 µg/ml. Predicted molecular weight: 38 kDa.
ELISA 1/16000.
IHC-P Use a concentration of 5 µg/ml.

Target

  • FunctionAntagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Tissue specificityHighest expression in heart, brain, and spinal cord.
  • Sequence similaritiesBelongs to the dickkopf family.
  • DomainThe C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Post-translational
    modifications
    N- and O-glycosylated.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dickkopf 3 antibody
    • Dickkopf 3 homolog (Xenopus laevis) antibody
    • Dickkopf 3 homolog antibody
    • Dickkopf homolog 3 antibody
    • Dickkopf related protein 3 antibody
    • Dickkopf related protein 3 Precursor antibody
    • Dickkopf WNT signaling pathway inhibitor 3 antibody
    • Dickkopf, Xenopus, homolog of, 3 antibody
    • Dickkopf-3 antibody
    • Dickkopf-related protein 3 antibody
    • Dickkopf3 antibody
    • DKK 3 antibody
    • Dkk-3 antibody
    • DKK3 antibody
    • DKK3_HUMAN antibody
    • hDkk 3 antibody
    • hDkk-3 antibody
    • hDkk3 antibody
    • Regulated in glioma antibody
    • REIC antibody
    • RIG antibody
    • RIG-like 5-6 antibody
    • RIG-like 7-1 antibody
    see all

Anti-Dkk3 antibody images

  • ab115869, at 5 µg/ml, staining Dkk3 in Formalin-fixed, Paraffin-embedded Human brain cortex by Immunohistochemistry.
  • Anti-Dkk3 antibody (ab115869) at 2 µg/ml + HEK293 lysate at 30 µg
    Developed using the ECL technique

    Predicted band size : 38 kDa

References for Anti-Dkk3 antibody (ab115869)

ab115869 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab115869.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"