The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent concentration. PubMed: 25093893
Use at an assay dependent concentration. PubMed: 19501574
1/500 - 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 32 kDa).
1/50 - 1/100.
FunctionLikely to play a regulatory role in the development of the ventral forebrain. May play a role in craniofacial patterning and morphogenesis.
Involvement in diseaseDefects in DLX3 are a cause of trichodentoosseous syndrome (TDO) [MIM:190320]. TDO is an autosomal dominant syndrome characterized by enamel hypoplasia and hypocalcification with associated strikingly curly hair. Defects in DLX3 are the cause of amelogenesis imperfecta type 4 (AI4) [MIM:104510]; also known as amelogenesis imperfecta hypomaturation-hypoplastic type with taurodontism. AI4 is an autosomal dominant defect of enamel formation associated with enlarged pulp chambers.
Sequence similaritiesBelongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain.
Gahring LC et al. Nicotinic receptor Alpha7 expression during mouse adrenal gland development. PLoS One9:e103861 (2014).
Read more (PubMed: 25093893) »
Wu LA et al. Development and characterization of a mouse floxed Bmp2 osteoblast cell line that retains osteoblast genotype and phenotype. Cell Tissue Res343:545-58 (2011).
Read more (PubMed: 21271257) »