Overview

  • Product nameAnti-DMAP1 antibody
    See all DMAP1 primary antibodies
  • Description
    Rabbit polyclonal to DMAP1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Cow, Dog, Human, Chimpanzee
    Predicted to work with: Chicken
  • Immunogen

    Synthetic peptide corresponding to a region between residues 250 -300 of human DMAP1.

  • Positive control
    • Human, mouse and rat brain lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab72072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notesIHC-P: Use at a concentration of 10 µg/ml.
    WB: Use at a concentration of 1 - 4 µg/ml. Detects bands of approximately 27,34 and 53 kDa (predicted molecular weight: 53 kDa).

    The approximately 27 kD band seen in brain lysate is also seen in the prebleed and not thought to be relevant.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceDMAP1 is involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
    • Cellular localizationNuclear
    • Database links
    • Alternative names
      • DKFZp686L09142 antibody
      • DMAP 1 antibody
      • DNA methyltransferase 1 associated protein 1 antibody
      • DNMAP 1 antibody
      • DNMAP1 antibody
      • DNMT1 associated protein 1 antibody
      • DNMTAP 1 antibody
      • DNMTAP1 antibody
      • EAF 2 antibody
      • EAF2 antibody
      • FLJ11543 antibody
      • KIAA1425 antibody
      • MAT 1 mediated transcriptional repressor antibody
      • MGC55593 antibody
      • SWC 4 antibody
      • SWC4 antibody
      • zgc:55593 antibody
      see all

    Anti-DMAP1 antibody images

    • Lanes 1 - 2 : Anti-DMAP1 antibody (ab72072) at 4 µg/ml
      Lanes 3 - 4 : Anti-DMAP1 antibody (ab72072) at 1 µg/ml

      Lane 1 : human brain lysate
      Lane 2 : human brain lysate plus immunizing peptide
      Lane 3 : mouse brain lysate
      Lane 4 : rat brain lysate


      Predicted band size : 53 kDa
      Observed band size : 53 kDa
      Additional bands at : 27 kDa,34 kDa. We are unsure as to the identity of these extra bands.

    References for Anti-DMAP1 antibody (ab72072)

    ab72072 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab72072.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"