Anti-DMAP1 antibody - Carboxyterminal end (ab71789)

Overview

  • Product nameAnti-DMAP1 antibody - Carboxyterminal end
    See all DMAP1 primary antibodies
  • Description
    Rabbit polyclonal to DMAP1 - Carboxyterminal end
  • Tested applicationsSuitable for: WB, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    A KLH conjugated synthetic peptide selected from the C-terminal region of human DMAP1.

  • Positive control
    • Human hepatocarcinoma tissue and HL60 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab71789 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).
ELISA 1/1000.
IHC-P 1/50 - 1/100.

Target

  • RelevanceDMAP1 is involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • DKFZp686L09142 antibody
    • DMAP 1 antibody
    • DNA methyltransferase 1 associated protein 1 antibody
    • DNMAP 1 antibody
    • DNMAP1 antibody
    • DNMT1 associated protein 1 antibody
    • DNMTAP 1 antibody
    • DNMTAP1 antibody
    • EAF 2 antibody
    • EAF2 antibody
    • FLJ11543 antibody
    • KIAA1425 antibody
    • MAT 1 mediated transcriptional repressor antibody
    • MGC55593 antibody
    • SWC 4 antibody
    • SWC4 antibody
    • zgc:55593 antibody
    see all

Anti-DMAP1 antibody - Carboxyterminal end images

  • Anti-DMAP1 antibody - Carboxyterminal end (ab71789) at 1/100 dilution + HL60 cell lysate at 12.5 µg

    Predicted band size : 53 kDa
    Observed band size : 53 kDa
  • Formalin-fixed, paraffin-embedded human hepatocarcinoma tissue reacted with ab71789 at a 1:50 dilution, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.

References for Anti-DMAP1 antibody - Carboxyterminal end (ab71789)

ab71789 has not yet been referenced specifically in any publications.

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