Overview

  • Product name
    DMAPT
  • Description
    NF-κB inhibitor
  • Alternative names
    • Dimethylaminoparthenolide
  • Biological description
    NF-κB inhibitor. Reduces NF-κB DNA binding. Shows antiproliferative effects (IC50 = 5-10 μM). Parthenolide (ab120849) analog. Epigenetic modulator, functions NFκB-dependently and independently. Generates ROS and shows antitumor effects in vivo. Orally active.

Properties

  • Chemical name
    (1aR,4E,7aS,8R,10aS,10bS)-8-[(Dimethylamino)methyl]-2,3,6,7,7a,8,10a,10b-octahydro-1a,5-dimethyl-oxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one
  • Molecular weight
    293.41
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C17H27NO3
  • CAS Number
    1070780-82-3
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Nakshatri H  et al. NF-?B-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death Dis 6:e1608 (2015). Read more (PubMed: 25611383) »
  • Burnett RM  et al. Organ-specific adaptive signaling pathway activation in metastatic breast cancer cells. Oncotarget 6:12682-96 (2015). Read more (PubMed: 25926557) »
  • Song JM  et al. Dimethylaminoparthenolide, a water soluble parthenolide, suppresses lung tumorigenesis through down-regulating the STAT3 signaling pathway. Curr Cancer Drug Targets 14:59-69 (2014). Read more (PubMed: 24200081) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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