Overview

  • Product nameAnti-DMGDH antibody
    See all DMGDH primary antibodies
  • Description
    Rabbit polyclonal to DMGDH
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to C terminal amino acids 776-859 (TLATDDVDPE GNESIWYNGK VVGNTTSGSY SYSIQKSLAF AYVPVQLSEV GQQVEVELLG KNYPAVIIQE PLVLTEPTRN RLQK) of Human DMGDH.

  • Positive control
    • Human kidney tissue.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab122336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • PathwayAmine and polyamine degradation; betaine degradation; sarcosine from betaine: step 2/2.
  • Involvement in diseaseDefects in DMGDH are the cause of DMGDH deficiency (DMGDHD) [MIM:605850]. DMGDHD is a disorder characterized by fish odor, muscle fatigue with increased serum creatine kinase. Biochemically it is characterized by an increase of N,N-dimethylglycine (DMG) in serum and urine.
  • Sequence similaritiesBelongs to the GcvT family.
  • Cellular localizationMitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dimethylglycine dehydrogenase antibody
    • Dimethylglycine dehydrogenase, mitochondrial antibody
    • Dmgdh antibody
    • M2GD_HUMAN antibody
    • ME2GLYDH antibody
    • mitochondrial antibody
    see all

Anti-DMGDH antibody images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling DMGDH with ab122336. Staining shows strong cytoplasmic positivity in renal tubules.

References for Anti-DMGDH antibody (ab122336)

ab122336 has not yet been referenced specifically in any publications.

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