Anti-DNA Polymerase beta (di methyl R83) antibody (ab93673)

Overview

  • Product name
    Anti-DNA Polymerase beta (di methyl R83) antibody
    See all DNA Polymerase beta primary antibodies
  • Description
    Rabbit polyclonal to DNA Polymerase beta (di methyl R83)
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Recombinant fragment
    Predicted to work with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to the N terminal residues of Human DNA Polymerase beta.

Properties

Applications

Our Abpromise guarantee covers the use of ab93673 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.
ELISA 1/2000 - 1/5000.

Target

  • Function
    Repair polymerase. Conducts "gap-filling" DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
  • Sequence similarities
    Belongs to the DNA polymerase type-X family.
  • Domain
    Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.
  • Post-translational
    modifications
    Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.
  • Cellular localization
    Nucleus, Cytoplasm
  • Information by UniProt
  • Database links
  • Alternative names
    • DNA directed DNA polymerase beta antibody
    • DNA pol beta antibody
    • DNA polymerase beta antibody
    • DNA polymerase beta subunit antibody
    • DPOLB_HUMAN antibody
    • MGC125976 antibody
    • Pol B antibody
    • Pol beta antibody
    • POLB antibody
    • Polymerase (DNA directed) beta antibody
    see all

References

ab93673 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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