Cellular Responses to DNA Damage 2008 conference

Venue:

Best Western: Inn at Longwood Medical
342 Longwood Avenue (map)
Boston, Massachusetts

Thursday, May 29, 2008

9:00am to 5:10pm.
Poster session and wine reception to follow.
Lunch is included.

Dr. Brendan Price and Dr. Ralph Scully in association with Abcam, Inc.

Contents:

About the meeting:

The symposium will explore the links between chromatin dynamics, histone modification and the repair of DNA double strand breaks. The compact nature of chromatin presents a significant barrier to DNA-dependent transactions, including gene transcription and DNA replication. Access to specific regions of chromatin is regulated at multiple levels, including remodeling of chromatin structure, local deposition of specific histone variants, post-translational modification of histones and the recruitment of specific proteins to these modified histones. The ability of cells to detect and repair DNA double strand breaks appears to be dependent on many of these same regulatory processes. By bringing together a diverse array of experts from the fields of chromatin structure, histone modification, chromatin remodeling and DNA double-strand break repair, this symposium aims to highlight the critical role of histones and chromatin structure in the detection and repair of DNA double strand breaks.

Topics to be discussed include:

• Higher order chromatin structures and double strand break repair.
• Chromatin remodeling complexes implicated in the repair of DNA breaks.
• Chromatin structure adjacent to DNA double strand breaks.
• The role of histones and histone modifications in DNA damage signaling, including key modifications such as H2AX phosphorylation, histone methylation and histone ubiquitination.
• Formation of DNA repair complexes at DNA double strand breaks.

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Invited speakers:

• Craig Peterson, UMass Medical School, Worcester, Massachusetts
  Regulation of chromatin dynamics at DNA double strand breaks
• Fred Alt, HHMI/The Children's Hospital, Boston, Massachusetts
  IgH class switching, DNA end-joining and translocations
• Craig Bassing, Children's Hospital of Philadelphia, Philadelphia, Pennsylvannia
  Dynamics of histone H2AX phosphorylation in chromatin around DNA breaks
• David Livingston, Dana-Farber Cancer Institute, Boston, Massachusetts
  Functional analysis of the BRCA1 gene product
• Marjorie Oettinger, Massachusetts General Hospital, Boston, Massachusetts
  RAG2 links histone methylation and VDJ recombination
• Evi Soutoglou, NCI, Bethesda, Maryland
  Nuclear architecture in the maintenance of genome integrity and DNA repair

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Additional speakers:

• Matthew Weitzman, Salk Institute, San Diego, California
  A viral ubiquitin ligase targets chromatin to prevent the accumulation of DNA repair proteins at sites of cellular damage
• Anyong Xie, Beth Israel Deaconess Medical Center, Boston, Massachusetts
  Histone H2AX-associated proteins MDC1 and 53BP1 in double strand break repair
• Wayne Lilyestrom, Colorado State University, Fort Collins, Colorado
  Understanding the interactions between parp-1, DNA and nucleosomes
• Philipp Oberdoerffer, Harvard Medical School, Boston, Massachusetts
  DNA damage-induced redistribution of SIRT1 contributes to genomic integrity and age-related changes in gene expression
• Simone Difilippantonio, NCI, Bethesda, Maryland
  53BP1 facilitates long-range DNA end-joining during V(D)J recombination
  

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Program:

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Registration:

$115 ($35 student and postdocs) Includes lunch, wine reception, and coffee breaks.
Register online.

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Abstract submission has closed for this meeting.

Accommodation:

Contact the Best Western: Inn at Longwood Medical at 1-800-GOT-BEST or 617-731-4700 to see if rooms are still available.

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Parking:

Public parking is available in the Best Western's garage for $28.00 for the full day. Please be aware that the garage takes cash only.

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Public transportation:

There are many MBTA bus stops close to the Best Western. The Longwood stop on Green Line D trolley is also within walking distance. Visit the MBTA website for more information on taking public transportation.

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Sponsorship:

If you are interested in sponsoring or exhibiting at this meeting, please contact us for more information.

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Katie Sedat, Abcam Events Team
Phone: 617-577-4263

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