• Product name
    Anti-DNAH10 antibody
  • Description
    Rabbit polyclonal to DNAH10
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 785-881 of Human DNAH10 (UniProt ID: Q8IVF4).

  • Positive control
    • Human pancreas tissue



Our Abpromise guarantee covers the use of ab122528 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. Use buffer at pH 6 for antigen retrieval.


  • Function
    Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Probable inner arm dynein heavy chain.
  • Tissue specificity
    Expressed primarily in trachea and testis, 2 tissues containing axonemal structures. Also expressed in brain but not in adult heart.
  • Sequence similarities
    Belongs to the dynein heavy chain family.
    Contains 5 TPR repeats.
  • Domain
    Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
  • Cellular localization
    Cytoplasm > cytoskeleton > cilium axoneme.
  • Information by UniProt
  • Database links
  • Alternative names
    • axonemal antibody
    • Axonemal beta dynein heavy chain 10 antibody
    • Ciliary dynein heavy chain 10 antibody
    • DNAH10 antibody
    • DYH10_HUMAN antibody
    • Dynein heavy chain 10 antibody
    • KIAA2017 antibody
    see all

Anti-DNAH10 antibody images

  • Immunohistochemical staining of DNAH10 in paraffin embedded Human pancreas tissue by Immunohistochemistry, using ab122528 at a 1/250 dilution. The image shows strong cytoplasmic positivity in exocrine glandular cells.

References for Anti-DNAH10 antibody (ab122528)

ab122528 has not yet been referenced specifically in any publications.

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