Overview

  • Product name
  • Description
    Rabbit polyclonal to DNAJC3
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Pig
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 270-492 of Human DNAJC3 (UniProt Q13217).

  • Positive control
    • 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab154714 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 58 kDa.

Target

  • Function
    Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.
  • Tissue specificity
    Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
  • Sequence similarities
    Contains 1 J domain.
    Contains 9 TPR repeats.
  • Domain
    The J domain mediates interaction with HSPA8.
  • Cellular localization
    Endoplasmic reticulum.
  • Information by UniProt
  • Database links
  • Alternative names
    • DnaJ (Hsp40) homolog subfamily C member 3 antibody
    • DnaJ homolog subfamily C member 3 antibody
    • DNAJC3 antibody
    • DNJC3_HUMAN antibody
    • double-stranded RNA-activated protein kinase inhibitor antibody
    • Endoplasmic reticulum DnaJ protein 6 antibody
    • ERdj6 antibody
    • HP58 antibody
    • Interferon induced, double stranded RNA activated protein kinase inhibitor antibody
    • Interferon-induced antibody
    • P58 antibody
    • p58 ipk antibody
    • P58IPK antibody
    • PRKRI antibody
    • Protein kinase inhibitor of 58 kDa antibody
    • Protein kinase inhibitor p58 antibody
    • Protein kinase interferon inducible double stranded RNA dependent inhibitor antibody
    see all

Images

  • All lanes : Anti-DNAJC3 antibody (ab154714) at 1/1000 dilution

    Lane 1 : A431 whole cell lysate
    Lane 2 : H1299 whole cell lysate
    Lane 3 : HeLa whole cell lysate
    Lane 4 : MOLT4 whole cell lysate
    Lane 5 : Raji whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 58 kDa



    7.5% SDS PAGE

References

ab154714 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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