Overview

  • Product nameDNMT1 Inhibitor Screening Assay Kit
    See all DNMT1 kits
  • Assay time
    3h 00m
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: all Mammals
  • Product overview

    DNMT1 (DNA (cytosine-5)-methyltransferase 1) belongs to the DNMT family, responsible for methylation of CpG islands in the genome. DNMT1 preferably methylates cytosines located in hemimethylated DNA and it associates with DNA replication sites in S-phase. The selective inhibition of DNMT1 may lead to demethylation and expression of silenced tumor suppressor genes. Thus, the selective DNMT1 inhibitors could be a new addition to cancer therapeutic agents.

    Abcam's DNMT1 Inhibitor Screening Assay Kit (ab113465) allows the user to selectively screen DNMT1 inhibitors quickly. The kit is ready-to-use and provides all the essential components needed to carry out a successful DNMT1 activity/inhibitor screening experiment without the need for radioactivity or any special equipment.

    Not sure if this is the right product for you? Check out our DNMT Product Guide for help.

  • Notes

     

     

  • Tested applicationsFunctional Studiesmore details

Properties

    Applications

    Our Abpromise guarantee covers the use of ab113465 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    DNMT1 Inhibitor Screening Assay Kit images

    • Recombinant DNMT1 was incubated with substrate and inhibitors. DNMT1 activity was measured using ab113465 in the presence or absence of inhibitors.

    Protocols

    References for DNMT1 Inhibitor Screening Assay Kit (ab113465)

    ab113465 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab113465.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"