Overview

  • Product nameDNQX disodium salt
  • Description
    AMPA / kainate antagonist; water soluble
  • Biological descriptionWater soluble AMPA / kainate antagonist.

    Also available in simple stock solutions (ab144496) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity> 99%

Properties

    Applications

    Our Abpromise guarantee covers the use of ab120169 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    Functional Studies Use at an assay dependent concentration.

    DNQX disodium salt images

    • ab96379 staining MEK1 (phospho S298) in SK-N-SH cells treated with DNQX disodium salt (ab120169), by ICC/IF. Decrease in MEK1 (phospho S298) expression correlates with increased concentration of DNQX disodium salt, as described in literature.
      The cells were incubated at 37°C for 3h in media containing different concentrations of ab120169 (DNQX disodium salt) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab96379 (1/100 dilution) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 goat anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

    References for DNQX disodium salt (ab120169)

    This product has been referenced in:
    • Watkins JC  et al. Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Adv Exp Med Biol 268:49-55 (1990). Read more (PubMed: 1963751) »
    • Davies SN & Collingridge GL Quinoxalinediones as excitatory amino acid antagonists in the vertebrate central nervous system. Int Rev Neurobiol 32:281-303 (1990). Read more (PubMed: 1981885) »
    • Honoré T  et al. Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241:701-3 (1988). Read more (PubMed: 2899909) »

    See all 8 Publications for this product

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    Regarding ab120044 and ab120169, we don't use HPLC to purify the product, it is used only to analyse it.Our methods of purification are proprietary. We would therefore ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"