Overview

  • Product name
  • Description
    Rabbit polyclonal to DOC2A
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
    Predicted to work with: Rat, Cow, Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 133-351 of Human DOC2A (UniProt Q14183).

  • Positive control
    • Mouse brain whole cell lysate.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 78% PBS, 20% Glycerol, 1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
    Polyclonal
  • Isotype
    IgG

Applications

Our Abpromise guarantee covers the use of ab155168 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 44 kDa.

Target

  • Function
    Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
  • Tissue specificity
    Predominantly expressed in brain. Also expressed in testis.
  • Sequence similarities
    Contains 2 C2 domains.
  • Domain
    C2 domain 1 is involved in binding calcium and phospholipids.
  • Cellular localization
    Lysosome. Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Cell junction > synapse > synaptosome. Colocalizes to synaptic vesicles.
  • Information by UniProt
  • Database links
  • Alternative names
    • Doc2 antibody
    • Doc2-alpha antibody
    • Doc2a antibody
    • DOC2A_HUMAN antibody
    • Double C2 domain alpha antibody
    • Double C2 like domains, alpha antibody
    • Double C2-like domain-containing protein alpha antibody
    see all

Images

  • Anti-DOC2A antibody (ab155168) at 1/1000 dilution + Mouse brain whole cell lysate at 50 µg

    Predicted band size: 44 kDa



    10% SDS PAGE

References

ab155168 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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