Overview

  • Product nameAnti-DOC2B antibody
    See all DOC2B primary antibodies
  • Description
    Rabbit polyclonal to DOC2B
  • SpecificityThis antibody will label both DOC2B proteins but will not label DOC2A subtype variants. This antibody does not cross react to other calcium binding proteins.
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Dog
  • Immunogen

    Synthetic peptide: IGKSNDFIGG VVLGIHAKGE RLKHWFDCLK NKDKRIERWH TLTSELPGAV LSD, corresponding to C terminal amino acids 360-412 of Human DOC2B

  • General notesStore undiluted

Properties

Applications

Our Abpromise guarantee covers the use of ab114864 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Predicted molecular weight: 46 kDa.
ELISA 1/10000.

Target

  • FunctionCalcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
  • Tissue specificityWidely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
  • Sequence similaritiesContains 2 C2 domains.
  • DomainC2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the calcium-dependent targeting to membranes.
  • Cellular localizationCytoplasm. Cytoplasmic granule. Cell membrane. Translocates to the plasma membrane in a calcium-dependent manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • Doc2 beta antibody
    • Doc2-beta antibody
    • Doc2b antibody
    • DOC2B_HUMAN antibody
    • DOC2BL antibody
    • Double C2 like domain containing protein beta antibody
    • Double C2 like domains beta antibody
    • Double C2 like domains beta like antibody
    • Double C2-like domain-containing protein beta antibody
    • OTTMUSP00000006522 antibody
    • RP23 78H4.2 antibody
    see all

References for Anti-DOC2B antibody (ab114864)

ab114864 has not yet been referenced specifically in any publications.

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