• Product nameAnti-DOC2B antibody
    See all DOC2B primary antibodies
  • Description
    Mouse polyclonal to DOC2B
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human DOC2B protein (AAI53025.1)

  • Positive control
    • Human kidney tissue lysate and DOC2B transfected 293T cell lysate.



Our Abpromise guarantee covers the use of ab88568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa.


  • FunctionCalcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
  • Tissue specificityWidely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
  • Sequence similaritiesContains 2 C2 domains.
  • DomainC2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the calcium-dependent targeting to membranes.
  • Cellular localizationCytoplasm. Cytoplasmic granule. Cell membrane. Translocates to the plasma membrane in a calcium-dependent manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • Doc2 beta antibody
    • Doc2-beta antibody
    • Doc2b antibody
    • DOC2B_HUMAN antibody
    • DOC2BL antibody
    • Double C2 like domain containing protein beta antibody
    • Double C2 like domains beta antibody
    • Double C2 like domains beta like antibody
    • Double C2-like domain-containing protein beta antibody
    • OTTMUSP00000006522 antibody
    • RP23 78H4.2 antibody
    see all

Anti-DOC2B antibody images

  • Anti-DOC2B antibody (ab88568) at 1 µg/ml + human kidney tissue lysate at 50 µg

    Predicted band size : 46 kDa
    Observed band size : 42 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-DOC2B antibody (ab88568) at 1 µg/ml

    Lane 1 : DOC2B transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Predicted band size : 46 kDa
    Observed band size : 46 kDa

References for Anti-DOC2B antibody (ab88568)

This product has been referenced in:
  • Oh E  et al. Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms. J Biol Chem 287:25821-33 (2012). WB . Read more (PubMed: 22685295) »

See 1 Publication for this product

Product Wall

Thank you for your message.

I can confirm we have received the Abreview. Thank you for your valuable feedback. One of our Abreviews team will be in touch with you soon. We receive many Abreviews and it can take up to 1 - 2 weeks to review an...

Read More