• Product name
    Anti-DOC2B antibody
  • Description
    Mouse polyclonal to DOC2B
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human DOC2B protein (AAI53025.1)

  • Positive control
    • Human kidney tissue lysate and DOC2B transfected 293T cell lysate.



Our Abpromise guarantee covers the use of ab88568 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 46 kDa.


  • Function
    Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes.
  • Tissue specificity
    Widely expressed with highest levels in brain and kidney. Expressed in pancreatic islet cells (at protein level).
  • Sequence similarities
    Contains 2 C2 domains.
  • Domain
    C2 domain 1 is involved in binding calcium and phospholipids. C2 domain 2 may also play a role in the calcium-dependent targeting to membranes.
  • Cellular localization
    Cytoplasm. Cytoplasmic granule. Cell membrane. Translocates to the plasma membrane in a calcium-dependent manner.
  • Information by UniProt
  • Database links
  • Alternative names
    • Doc2 beta antibody
    • Doc2-beta antibody
    • Doc2b antibody
    • DOC2B_HUMAN antibody
    • DOC2BL antibody
    • Double C2 like domain containing protein beta antibody
    • Double C2 like domains beta antibody
    • Double C2 like domains beta like antibody
    • Double C2-like domain-containing protein beta antibody
    • OTTMUSP00000006522 antibody
    • RP23 78H4.2 antibody
    see all

Anti-DOC2B antibody images

  • Anti-DOC2B antibody (ab88568) at 1 µg/ml + human kidney tissue lysate at 50 µg

    Predicted band size : 46 kDa
    Observed band size : 42 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-DOC2B antibody (ab88568) at 1 µg/ml

    Lane 1 : DOC2B transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Predicted band size : 46 kDa
    Observed band size : 46 kDa

References for Anti-DOC2B antibody (ab88568)

This product has been referenced in:
  • Oh E  et al. Munc18-1 Regulates First-phase Insulin Release by Promoting Granule Docking to Multiple Syntaxin Isoforms. J Biol Chem 287:25821-33 (2012). WB . Read more (PubMed: 22685295) »

See 1 Publication for this product

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