Overview

  • Product nameAnti-DOCK1 antibody
    See all DOCK1 primary antibodies
  • Description
    Rabbit polyclonal to DOCK1
  • Specificityab92710 detects endogenous levels of total DOCK1 protein.
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide derived from an internal region of Human DOCK1.

  • Positive control
    • HeLa cell lysate

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab92710 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
WB
  • Application notesELISA: 1/40000.
    WB: 1/500 - 1/1000. Predicted molecular weight: 215 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInvolved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1.
    • Tissue specificityHighly expressed in placenta, lung, kidney, pancreas and ovary. Expressed at intermediate level in thymus, testes and colon.
    • Sequence similaritiesBelongs to the DOCK family.
      Contains 1 DHR-1 (CZH-1) domain.
      Contains 1 DHR-2 (CZH-2) domain.
      Contains 1 SH3 domain.
    • DomainThe DHR-2 domain is necessary and sufficient for the GEF activity.
    • Cellular localizationCytoplasm. Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-triphosphate.
    • Information by UniProt
    • Database links
    • Alternative names
      • 180 kDa protein downstream of CRK antibody
      • Ced5 antibody
      • Dedicator of Cytokinesis 1 antibody
      • Dedicator of cytokinesis protein 1 antibody
      • DOCK 1 antibody
      • DOCK 180 antibody
      • DOCK1 antibody
      • DOCK1_HUMAN antibody
      • DOCK180 antibody
      see all

    Anti-DOCK1 antibody images

    • All lanes : Anti-DOCK1 antibody (ab92710) at 1/500 dilution

      Lane 1 : HeLa cell lysate
      Lane 2 : HeLa cell lysate with immunizing peptide at 10 µg

      Lysates/proteins at 30 µg per lane.


      Predicted band size : 215 kDa

    References for Anti-DOCK1 antibody (ab92710)

    ab92710 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab92710.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"