Overview

  • Product nameAnti-DOCK3 antibody
  • Description
    Rabbit polyclonal to DOCK3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 400 - 500 of Human DOCK3.

    (Peptide available as ab86183.)

  • Positive control
    • This antibody gave a positive signal in Mouse Brain Tissue Lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab75911 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 233 kDa (predicted molecular weight: 233 kDa).

Target

  • RelevanceDOCK3 is a potential Guanine Nucleotide Exchange factor, present predominantly in brain. DOCK3 is localised in the neuropil and occasionally in the pyramidal cells. In brains of patients with Alzheimer's disease, it is associated with neurofibrillary tangles. DOCK3 may be required for maintaining the functional integrity of axons and loss of DOCK3 may result in axonal degeneration. It is associated with behavioural/developmental conditions like Attention Deficit Hyperactivity disorder.
  • Cellular localizationCytoplasmic
  • Database links
  • Alternative names
    • Dedicator of cytokinesis protein 3 antibody
    • DOCK 3 antibody
    • MOCA antibody
    • Modifier of cell adhesion antibody
    • Presenilin binding protein antibody
    see all

Anti-DOCK3 antibody images

  • Anti-DOCK3 antibody (ab75911) at 1 µg/ml + Mouse Brain Tissue Lysate at 10 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size : 233 kDa
    Observed band size : 233 kDa

References for Anti-DOCK3 antibody (ab75911)

This product has been referenced in:
  • Seo M  et al. RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways. Nat Commun 5:5217 (2014). Read more (PubMed: 25347953) »
  • Ladhani O  et al. Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis. Neoplasia 13:633-42 (2011). WB ; Human . Read more (PubMed: 21750657) »

See all 2 Publications for this product

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1. Is same positive control mouse brain lysate still giving a clean band?
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