Overview

  • Product nameAnti-DOCK4 antibody
    See all DOCK4 primary antibodies
  • Description
    Rabbit polyclonal to DOCK4
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region within internal sequence amino acids 1725-1775 of Human DOCK4 (NP_055520.3).

  • Positive control
    • Human Ovarian and Prostate Carcinoma tissues.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.09% Sodium azide
    Constituents: 99% Tris buffered saline, 0.1% BSA
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab111876 is affinity purified using an epitope specific to DOCK4 immobilized on solid support.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • FunctionInvolved in regulation of adherens junction between cells. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.
  • Tissue specificityWidely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.
  • Sequence similaritiesBelongs to the DOCK family.
    Contains 1 DHR-1 (CZH-1) domain.
    Contains 1 DHR-2 (CZH-2) domain.
    Contains 1 SH3 domain.
  • DomainThe DHR-2 domain probably mediates the GEF activity.
  • Cellular localizationEndomembrane system.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dedicator of cytokinesis protein 4 antibody
    • Dock4 antibody
    • DOCK4_HUMAN antibody
    • KIAA0716 antibody

Anti-DOCK4 antibody images

  • ab111876 at 1/250 dilution staining DOCK4 in Formalin-fixed, Paraffin-embedded Human ovarian carcinoma tissue by Immunohistochemistry. Detection: DAB staining.
  • ab111876 at 1/250 dilution staining DOCK4 in Formalin-fixed, Paraffin-embedded Human Prostate carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

References for Anti-DOCK4 antibody (ab111876)

ab111876 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab111876.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"