Overview

  • Product name
  • Description
    Rabbit polyclonal to DOCK4
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide, corresponding to a region within internal sequence amino acids 1725-1775 of Human DOCK4 (NP_055520.3).

  • Positive control
    • Human Ovarian and Prostate Carcinoma tissues.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituents: 99% Tris buffered saline, 0.1% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    ab111876 is affinity purified using an epitope specific to DOCK4 immobilized on solid support.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab111876 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Involved in regulation of adherens junction between cells. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP.
  • Tissue specificity
    Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.
  • Sequence similarities
    Belongs to the DOCK family.
    Contains 1 DHR-1 (CZH-1) domain.
    Contains 1 DHR-2 (CZH-2) domain.
    Contains 1 SH3 domain.
  • Domain
    The DHR-2 domain probably mediates the GEF activity.
  • Cellular localization
    Endomembrane system.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dedicator of cytokinesis protein 4 antibody
    • Dock4 antibody
    • DOCK4_HUMAN antibody
    • KIAA0716 antibody

Images

  • ab111876 at 1/250 dilution staining DOCK4 in Formalin-fixed, Paraffin-embedded Human ovarian carcinoma tissue by Immunohistochemistry. Detection: DAB staining.
  • ab111876 at 1/250 dilution staining DOCK4 in Formalin-fixed, Paraffin-embedded Human Prostate carcinoma tissue by Immunohistochemistry. Detection: DAB staining.

References

ab111876 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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