Anti-DOK1 antibody - Aminoterminal end (ab53183)

Overview

  • Product name
    Anti-DOK1 antibody - Aminoterminal end
    See all DOK1 primary antibodies
  • Description
    Rabbit polyclonal to DOK1 - Aminoterminal end
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to N terminal of human DOK1 protein.

  • Positive control
    • K562 cells. Breast carcinoma

Properties

Applications

Our Abpromise guarantee covers the use of ab53183 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notes
    IHC-P: 1/50.

    Staining of formalin-fixed tissues requires boiling tissue sections in 10mM
    citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
    • Tissue specificity
      Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells.
    • Sequence similarities
      Belongs to the DOK family. Type A subfamily.
      Contains 1 IRS-type PTB domain.
      Contains 1 PH domain.
    • Domain
      The PTB domain mediates receptor interaction.
    • Post-translational
      modifications
      Constitutively tyrosine-phosphorylated.
      Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway.
    • Cellular localization
      Cytoplasm and Cytoplasm > perinuclear region.
    • Information by UniProt
    • Database links
    • Alternative names
      • Docking protein 1 62kD antibody
      • Docking protein 1 antibody
      • DOK 1 antibody
      • DOK1 antibody
      • DOK1_HUMAN antibody
      • Downstream of tyrosine kinase 1 antibody
      • p62(dok) antibody
      • P62DOK antibody
      • pp62 antibody
      see all

    References

    ab53183 has not yet been referenced specifically in any publications.

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