Anti-DOK7 antibody (ab75049)


  • Product nameAnti-DOK7 antibody
    See all DOK7 primary antibodies
  • Description
    Rabbit polyclonal to DOK7
  • Tested applicationsSuitable for: WB, IHC-P, Indirect ELISA, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide derived from N-terminus of human DOK7.

  • Positive control
    • human brain tissue, HepG2 cells, extracts from mouse brain cells.



Our Abpromise guarantee covers the use of ab75049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 53 kDa (predicted molecular weight: 53 kDa).
IHC-P 1/50 - 1/100.
Indirect ELISA 1/5000.
ICC/IF 1/500 - 1/1000.


  • FunctionProbable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
  • Tissue specificityPreferentially expressed in skeletal muscle and heart Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level).
  • Involvement in diseaseDefects in DOK7 are the cause of familial limb-girdle myasthenia autosomal recessive (LGM) [MIM:254300]; also called congenital myasthenic syndrome type 1B or CMS1B. LGM is a congenital myasthenic syndrome characterized by a typical 'limb girdle' pattern of muscle weakness with small, simplified neuromuscular junctions but normal acetylcholine receptor and acetylcholinesterase function.
  • Sequence similaritiesContains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • Cellular localizationCell membrane. Cell junction > synapse. Accumulates at neuromuscular junctions.
  • Information by UniProt
  • Database links
  • Alternative names
    • Docking protein 7 antibody
    • DOK 7 antibody
    • DOK7 antibody
    • DOK7_HUMAN antibody
    • Downstream of tyrosine kinase 7 antibody
    • Protein Dok-7 antibody
    see all

Anti-DOK7 antibody images

  • Human brain tissue with ab75049 at 1/50 dilution, in the absence and presence of the immunising peptide.
  • HepG2 cells with ab75049 at 1/500 dilution, in the absence and presence of the immunising peptide.
  • All lanes : Anti-DOK7 antibody (ab75049) at 1/500 dilution

    Lane 1 : extracts from mouse brain cells
    Lane 2 : extracts from mouse brain cells with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.

    Predicted band size : 53 kDa
    Observed band size : 53 kDa
    Additional bands at : 46 kDa,80 kDa. We are unsure as to the identity of these extra bands.

References for Anti-DOK7 antibody (ab75049)

ab75049 has not yet been referenced specifically in any publications.

Product Wall

Application Immunohistochemistry (Frozen sections)
Sample Rat Tissue sections (Tibialis anterior muscle)
Specification Tibialis anterior muscle
Fixative Paraformaldehyde
Permeabilization Yes - Triton X-100, 3% in TBS

Mr. Alejandro Gomez

Verified customer

Submitted Sep 10 2012


Expiration date: 05. October 2012

I am very pleased to hear you would like to accept our offer and test ab75049 in IHC-Fr. This code will give you: the value of ab75049 a future order before the expiratio...

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