Overview

  • Product name
    Domiphen bromide
  • Description
    Quaternary ammonium antiseptic. Potent HERG channel inhibitor.
  • Alternative names
    • (Dodecyldimethyl-2-phenoxyethyl)ammonium bromide
    • Bradasol
    • Bradonit
    • Bradoral
    • DMB
    • Dodecyl-dimethyl-(2-phenoxyethyl)azanium;bromide
    • Domifen bromide
    • Phenododecinium bromidel
    see all
  • Biological description

    Quaternary ammonium antiseptic. Inhibits HERG (ether-a-go-go related gene) potassium channels in a dose-dependent manner (IC50 = 9nM).

  • Purity
    > 99%

Properties

  • Chemical name
    Dodecyldimethyl-(2-phenoxyethyl)azanium bromide
  • Molecular weight
    414.46
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C22H40NO.Br
  • CAS Number
    538-71-6
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO to 100 mM, in water to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Long Y  et al. Inhibition of HERG potassium channels by domiphen bromide and didecyl dimethylammonium bromide. Eur J Pharmacol 737:202-9 (2014). Read more (PubMed: 24846011) »
  • Gao P  et al. Identification and validation of a novel lead compound targeting 4-diphosphocytidyl-2-C-methylerythritol synthetase (IspD) of mycobacteria. Eur J Pharmacol 694:45-52 (2012). Read more (PubMed: 22975264) »

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