Anti-DOPA Decarboxylase/DDC antibody (ab3905)
Key features and details
- Rabbit polyclonal to DOPA Decarboxylase/DDC
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
Overview
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Product name
Anti-DOPA Decarboxylase/DDC antibody
See all DOPA Decarboxylase/DDC primary antibodies -
Description
Rabbit polyclonal to DOPA Decarboxylase/DDC -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Rat -
Immunogen
Recombinant fragment corresponding to Bovine DOPA Decarboxylase/DDC. expressed in E. coli and purified from inclusion bodies
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.50
Preservative: 0.1% Sodium azide
Constituents: PBS, 0.316% Tris HCl, 0.05% Tween, 0.238% HEPES, 10% Glycerol, 0.1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab3905 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (1) |
Use a concentration of 0.1 - 0.5 µg/ml.
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Notes |
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WB
Use a concentration of 0.1 - 0.5 µg/ml. |
Target
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Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. -
Pathway
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2. -
Involvement in disease
Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive. -
Sequence similarities
Belongs to the group II decarboxylase family. - Information by UniProt
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Database links
- Entrez Gene: 13195 Mouse
- Entrez Gene: 24311 Rat
- SwissProt: O88533 Mouse
- SwissProt: P14173 Rat
- Unigene: 12906 Mouse
- Unigene: 11064 Rat
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Alternative names
- AADC antibody
- Aromatic L Amino Acid Decarboxylase antibody
- Aromatic-L-amino-acid decarboxylase antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (30)
ab3905 has been referenced in 30 publications.
- Seebauer L et al. Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells. Int J Mol Sci 23:N/A (2022). PubMed: 35163733
- Sheng KY et al. A region-dependent allele-biased expression of Dopa decarboxylase in mouse brain. Front Cell Dev Biol 10:1078927 (2022). PubMed: 36568970
- Raina A et al. Dopamine promotes the neurodegenerative potential of ß-synuclein. J Neurochem 156:674-691 (2021). PubMed: 32730640
- Chen X et al. Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression. Aging (Albany NY) 12:3042-3052 (2020). PubMed: 32074509
- Kao CY et al. Elevated COUP-TFII expression in dopaminergic neurons accelerates the progression of Parkinson's disease through mitochondrial dysfunction. PLoS Genet 16:e1008868 (2020). PubMed: 32579581