Anti-DOPA Decarboxylase antibody - N-terminal (ab189101)

Overview

  • Product name
    Anti-DOPA Decarboxylase antibody - N-terminal
    See all DOPA Decarboxylase primary antibodies
  • Description
    Rabbit polyclonal to DOPA Decarboxylase - N-terminal
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Cow, Human
    Predicted to work with: Rat, Sheep, Guinea pig, Dog
  • Immunogen

    Synthetic peptide corresponding to Human DOPA Decarboxylase (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). (NP_000781)
    Database link: P20711

  • Positive control
    • Human caudate and bovine adrenal medulla lysates; Human kidney tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab189101 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
WB 1/1000. Predicted molecular weight: 53 kDa.

Target

  • Function
    Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
  • Pathway
    Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
  • Involvement in disease
    Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
  • Sequence similarities
    Belongs to the group II decarboxylase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • AADC antibody
    • Aromatic L Amino Acid Decarboxylase antibody
    • Aromatic-L-amino-acid decarboxylase antibody
    • DDC antibody
    • DDC_HUMAN antibody
    • DOPA decarboxylase (aromatic L-amino acid decarboxylase) antibody
    • DOPA decarboxylase antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling DOPA Decarboxylase with ab189101 at 1/100.

  • Anti-DOPA Decarboxylase antibody - N-terminal (ab189101) at 1/1000 dilution + Human caudate lysate at 20 µg

    Predicted band size : 53 kDa
  • Anti-DOPA Decarboxylase antibody - N-terminal (ab189101) at 1/1000 dilution + Bovine adrenal medulla lysate at 5 µg

    Predicted band size : 53 kDa

References

ab189101 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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