Anti-Dopamine beta Hydroxylase antibody [8.F.304] (ab31126)

Overview

  • Product nameAnti-Dopamine beta Hydroxylase antibody [8.F.304]
    See all Dopamine beta Hydroxylase primary antibodies
  • Description
    Mouse monoclonal [8.F.304] to Dopamine beta Hydroxylase
  • Tested applicationsSuitable for: ELISA, ICC, WB, RIDmore details
  • Species reactivity
    Reacts with: Rat
    Does not react with: Mouse, Rabbit, Guinea pig, Cat, Human
  • Immunogen

    Full length protein (Rat)

Properties

Applications

Our Abpromise guarantee covers the use of ab31126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution.
ICC Use at an assay dependent dilution.
WB Use at an assay dependent dilution.
RID Use at an assay dependent dilution.

Target

  • FunctionConversion of dopamine to noradrenaline.
  • PathwayCatecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
  • Involvement in diseaseDefects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
  • Sequence similaritiesBelongs to the copper type II ascorbate-dependent monooxygenase family.
    Contains 1 DOMON domain.
  • Cellular localizationCytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • dbh antibody
    • DBM antibody
    • Dopamine beta hydroxylase antibody
    • Dopamine beta monooxygenase antibody
    • Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody
    • Dopamine beta-monooxygenase antibody
    • DOPO_HUMAN antibody
    • OTTHUMP00000022501 antibody
    • Soluble dopamine beta-hydroxylase antibody
    see all

References for Anti-Dopamine beta Hydroxylase antibody [8.F.304] (ab31126)

This product has been referenced in:
  • Coll M  et al. Down-regulation of genes related to the adrenergic system may contribute to splanchnic vasodilation in rat portal hypertension. J Hepatol 49:43-51 (2008). WB ; Rat . Read more (PubMed: 18457899) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"