Anti-Dopamine beta Hydroxylase antibody (ab27956)

Overview

  • Product name
    Anti-Dopamine beta Hydroxylase antibody
    See all Dopamine beta Hydroxylase primary antibodies
  • Description
    Sheep polyclonal to Dopamine beta Hydroxylase
  • Specificity
    ab27956 recognises Dopamine ß-Hydroxylase.
  • Tested applications
    Suitable for: WB, Dot blotmore details
  • Species reactivity
    Reacts with: Rabbit, Cow, Human, Monkey
  • Immunogen

    Synthetic peptide from the C-terminal region of human DBH.

  • Positive control
    • Human adrenal medulla lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab27956 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 68 kDa.
Dot blot 1/1000.

Target

  • Function
    Conversion of dopamine to noradrenaline.
  • Pathway
    Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
  • Involvement in disease
    Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
  • Sequence similarities
    Belongs to the copper type II ascorbate-dependent monooxygenase family.
    Contains 1 DOMON domain.
  • Cellular localization
    Cytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • dbh antibody
    • DBM antibody
    • Dopamine beta hydroxylase antibody
    • Dopamine beta monooxygenase antibody
    • Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody
    • Dopamine beta-monooxygenase antibody
    • DOPO_HUMAN antibody
    • OTTHUMP00000022501 antibody
    • Soluble dopamine beta-hydroxylase antibody
    see all

Images

References

ab27956 has not yet been referenced specifically in any publications.

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