Anti-Dopamine beta Hydroxylase antibody (ab63939)

Overview

  • Product nameAnti-Dopamine beta Hydroxylase antibody
    See all Dopamine beta Hydroxylase primary antibodies
  • Description
    Rabbit polyclonal to Dopamine beta Hydroxylase
  • Tested applicationsSuitable for: IHC-P, WB, ELISA, Radioimmunoprecipitation, Inhibition Assaymore details
  • Species reactivity
    Reacts with: Rat, Guinea pig, Cow, Human
  • Immunogen

    Full length native protein (purified) from bovine adrenal glands

Properties

Applications

Our Abpromise guarantee covers the use of ab63939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/2000.
WB 1/2000. Predicted molecular weight: 67 kDa. Pre-incubation with the enzyme abolished staining.
ELISA 1/5000.
Radioimmunoprecipitation Use at an assay dependent concentration.
Inhibition Assay Use at an assay dependent concentration.

Target

  • FunctionConversion of dopamine to noradrenaline.
  • PathwayCatecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1.
  • Involvement in diseaseDefects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also known as norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
  • Sequence similaritiesBelongs to the copper type II ascorbate-dependent monooxygenase family.
    Contains 1 DOMON domain.
  • Cellular localizationCytoplasmic vesicle > secretory vesicle lumen. Cytoplasmic vesicle > secretory vesicle > chromaffin granule lumen and Cytoplasmic vesicle > secretory vesicle membrane. Cytoplasmic vesicle > secretory vesicle > chromaffin granule membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • dbh antibody
    • DBM antibody
    • Dopamine beta hydroxylase antibody
    • Dopamine beta monooxygenase antibody
    • Dopamine beta-hydroxylase (dopamine beta-monooxygenase) antibody
    • Dopamine beta-monooxygenase antibody
    • DOPO_HUMAN antibody
    • OTTHUMP00000022501 antibody
    • Soluble dopamine beta-hydroxylase antibody
    see all

Anti-Dopamine beta Hydroxylase antibody images

  • Immunohistochemical analysis of guinea pig brain stem, staining Dopamine beta Hydroxylase using ab63939 at 1/1000.

References for Anti-Dopamine beta Hydroxylase antibody (ab63939)

This product has been referenced in:
  • Zhang J  et al. Adrenergic activation of electrogenic K+ secretion in guinea pig distal colonic epithelium: desensitization via the Y2-neuropeptide receptor. Am J Physiol Gastrointest Liver Physiol 297:G278-91 (2009). IF, IHC ; Guinea pig . Read more (PubMed: 19497958) »

See 1 Publication for this product

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As far as we are aware, specific protocol is not required for this antibody which means any general IHC-P protocol would work. I am sorry to hear that the antibody did not work with your protocol so in order to unders...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"