Anti-Dopamine Receptor D3 antibody (ab125467)

Overview

  • Product nameAnti-Dopamine Receptor D3 antibody
    See all Dopamine Receptor D3 primary antibodies
  • Description
    Rabbit polyclonal to Dopamine Receptor D3
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Dog, African Green Monkey
  • Immunogen

    Synthetic peptide corresponding to a region within the C terminal amino acids 270-319 (QERGGELKRE EKTRNSLMPL REKKATQMVA IVLGAFIVCW LPFFLTHVLN) of the Human Dopamine Receptor D3 protein (NP_387512).

  • Positive control
    • HepG2 cell lysate.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferConstituents: 97% PBS, 2% Sucrose
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab125467 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 41 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionThis is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation.
  • Tissue specificityBrain.
  • Involvement in diseaseGenetic variation in DRD3 is associated with essential tremor hereditary type 1 (ETM1) [MIM:190300]. ETM1 is the most common movement disorder. The main feature is postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications
    Phosphorylated by GRK4 (GRK4-alpha and GRK4-gamma).
  • Cellular localizationCell membrane. Both membrane-bound and scattered in the cytoplasm during basal conditions. Receptor stimulation results in the rapid internalization and sequestration of the receptors at the perinuclear area (5 and 15 minutes), followed by the dispersal of the receptors to the membrane (30 minutes). DRD3 and GRK4 co-localize in lipid rafts of renal proximal tubule cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • 3dopamine receptor antibody
    • D antibody
    • D(3) dopamine receptor antibody
    • Dopamine D3 receptor antibody
    • Dopamine receptor D3 antibody
    • DRD3 antibody
    • DRD3_HUMAN antibody
    • ETM1 antibody
    • FET1 antibody
    see all

Anti-Dopamine Receptor D3 antibody images

  • Anti-Dopamine Receptor D3 antibody (ab125467) at 1 µg/ml + HepG2 cell lysate at 10 µg

    Predicted band size : 41 kDa

References for Anti-Dopamine Receptor D3 antibody (ab125467)

ab125467 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab125467.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"