Overview

  • Product nameAnti-DORFIN antibody
    See all DORFIN primary antibodies
  • Description
    Rabbit polyclonal to DORFIN
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 383-413 of Human DORFIN (NP_056250.3, NP_904355.1).

  • Positive control
    • NCI-H460 cell line lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab123343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 65 kDa.

Target

  • FunctionE3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
  • Tissue specificityWidely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
  • PathwayProtein modification; protein ubiquitination.
  • Sequence similaritiesBelongs to the RBR family. RNF19 subfamily.
    Contains 1 IBR-type zinc finger.
    Contains 2 RING-type zinc fingers.
  • Post-translational
    modifications
    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localizationMembrane. Cytoplasm > cytoskeleton > centrosome. Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
  • Information by UniProt
  • Database links
  • Alternative names
    • AA032313 antibody
    • DKFZP566B1346 antibody
    • Dorfin antibody
    • Double ring finger protein antibody
    • Double ring-finger protein antibody
    • E3 ubiquitin-protein ligase RNF19A antibody
    • p38 antibody
    • p38 protein antibody
    • Ring finger protein 19 antibody
    • RING finger protein 19A antibody
    • Ring IBR ring domain containing protein Dorfin antibody
    • RN19A_HUMAN antibody
    • RNF19 antibody
    • RNF19A antibody
    • Ubce7ip2 antibody
    • UIP117 antibody
    • XYbp antibody
    see all

Anti-DORFIN antibody images

  • Anti-DORFIN antibody (ab123343) at 1/100 dilution + NCI-H460 cell line lysates at 35 µg

    Predicted band size : 65 kDa

References for Anti-DORFIN antibody (ab123343)

ab123343 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"