Overview

  • Product name
    Dorsomorphin (Compound C)
  • Description
    Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
  • Alternative names
    • Compound C
  • Biological description
    Potent, selective and reversible inhibitor of AMP-kinase (Ki = 109 nM). Inhibits AMPK activation induced by AICAR (ab120358) and metformin (ab120847). Selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Does not affect ZAPK, SYK, PKCθ, PKA and JAK3. Cell-permeable.
    Also available in a water soluble form (Dorsomorphin dihydrochloride - ab144821)
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Vucicevic L  et al. Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway. Autophagy 7:40-50 (2011). Read more (PubMed: 20980833) »
  • Kudo TA  et al. Dorsomorphin stimulates neurite outgrowth in PC12 cells via activation of a protein kinase A-dependent MEK-ERK1/2 signaling pathway. Genes Cells 16:1121-32 (2011). Read more (PubMed: 21988724) »
  • Zhou G  et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-74 (2001). Read more (PubMed: 11602624) »

See all 5 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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