Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor (ab146597)
Key features and details
- Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling.
- CAS Number: 866405-64-3
- Purity: > 99%
- Supplied in DMSO (10mM)
- Form / State: Liquid
- Source: Synthetic
Overview
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Product name
Dorsomorphin (Compound C) (DMSO solution), AMP-kinase inhibitor -
Description
Potent, selective and reversible AMP-kinase inhibitor. Selective for BMP signaling. -
Purity
> 99% -
General notes
A natural process can cause the product to crystallize out of solution. Should it happen, it is advised to heat the solution to approximately 55°C and let it cool down before use.
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CAS Number
866405-64-3 -
Chemical structure
Properties
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Chemical name
6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)pyrazolo[1,5-a]pyrimidine -
Molecular weight
399.49 -
Molecular formula
C24H25N5O -
PubChem identifier
11524144 -
Storage instructions
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes. -
Solubility overview
Supplied in DMSO (10mM) -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
c1c(cnc2c(cnn12)c3ccncc3)c5ccc(OCCN4CCCCC4)cc5 -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Images
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (4)
ab146597 has been referenced in 4 publications.
- Liu H et al. Bakuchiol Attenuates Oxidative Stress and Neuron Damage by Regulating Trx1/TXNIP and the Phosphorylation of AMPK After Subarachnoid Hemorrhage in Mice. Front Pharmacol 11:712 (2020). PubMed: 32499702
- Fujiwara H et al. Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation. Sci Rep 9:18859 (2019). PubMed: 31827136
- Guo H et al. Remote limb ischemic postconditioning protects against cerebral ischemia-reperfusion injury by activating AMPK-dependent autophagy. Brain Res Bull 139:105-113 (2018). PubMed: 29452253
- Blair JD et al. Genetically engineered human cortical spheroid models of tuberous sclerosis. Nat Med 24:1568-1578 (2018). PubMed: 30127391