Overview

  • Product nameDoxorubicin hydrochloride
  • Description
    Topoisomerase II inhibitor. Antibiotic with cytotoxic actions.
  • Alternative names
    • Adriamycin
  • Biological description

    Topoisomerase II inhibitor (IC50 = 100 nM, Hep3B cells). DNA intercalator that prevents synthesis of nucleic acid. Induces apoptosis.

  • Purity> 98%

Properties

    References for Doxorubicin hydrochloride (ab120629)

    This product has been referenced in:
    • Sauter KA  et al. Doxorubicin and daunorubicin induce processing and release of interleukin-1ß through activation of the NLRP3 inflammasome. Cancer Biol Ther 11:1008-16 (2011). Read more (PubMed: 21464611) »
    • Lal S  et al. Pharmacogenetics of target genes across doxorubicin disposition pathway: a review. Curr Drug Metab 11:115-28 (2010). Read more (PubMed: 20302569) »
    • Gieseler F  et al. Cytotoxicity of anthracyclines: correlation with cellular uptake, intracellular distribution and DNA binding. Ann Hematol 69 Suppl 1:S13-7 (1994). Read more (PubMed: 8061108) »

    See 1 Publication for this product

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