Overview

  • Product name
  • Description
    Rabbit polyclonal to DP1
  • Tested applications
    Suitable for: WB, IPmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide corresponding to Human DP1 aa 1-50 (N terminal). 50 amino acid range mapping within amino acids 1-50 DP-1.

  • Positive control
    • A431 or Raji cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab44999 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 45 kDa.
IP 1/2000.

Target

  • Function
    Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F-1/DP complex appears to mediate both cell proliferation and apoptosis.
  • Tissue specificity
    Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.
  • Sequence similarities
    Belongs to the E2F/DP family.
  • Post-translational
    modifications
    Phosphorylation by E2F-1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • DP 1 antibody
    • DP1 antibody
    • DRTF1 antibody
    • DRTF1-polypeptide 1 antibody
    • E2F dimerization partner 1 antibody
    • E2F related transcription factor antibody
    • TFDP1 antibody
    • TFDP1_HUMAN antibody
    • Transcription factor Dp-1 antibody
    • Transcription factor sequence-specific, DRTF1 antibody
    see all

References

ab44999 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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